TV Guide Box Hits Wednesday

Sheldon becomes concerned that his comfortable lifestyle is having an impact on his professional progress and is stopping him from achieving scientific greatness, so he asks the gang to make life more difficult for him. Meanwhile, Howard invents an unflattering game about Raj. Starring Jim Parsons and Simon Helberg

Leonard and Sheldon are forced to defend themselves against criticism from an online bully after publishing a physics paper. Meanwhile, the girls confront embarrassing moments from their pasts during a night in. Comedy, guest starring Stephen Hawking, with Johnny Galecki, Jim Parsons and Kaley Cuoco

Katherine Ryan nudges Jimmy Carr out of the hosting chair, inviting Roisin Conaty and Jessica Hynes to take on Sara Pascoe and Lolly Adefope in an all-female edition, originally shown to mark 100 years of women's suffrage. Rachel Riley is at the letters and numbers board, while Morgana Robinson appears in character as EastEnders' Natalie Cassidy alongside wordsmith Susie Dent in Dictionary Corner

Chef Gordon Ramsay heads to Mike & Nellie's Steakhouse in Oakhurst, New Jersey, where owner Mike Farber is mourning his father Nellie, who was also his business partner. Having been called in by the restaurateur's two daughters, Gordon faces the task of getting him to focus on his business, before tackling the bigger problem of rotting decor and a less-than-appealing menu

Mark is intent on winning the woman of his dreams, regardless of the fact that she already has a husband, and goes to some extraordinary lengths to do so - including a joint trip to the skin clinic for mole-mapping. On the other hand, Jeremy is determined to get his life on track and not ruin his new relationship. However, trouble seems to follow him around, and when Super Hans asks him to help out a friend, it could spell the end for the El Dude Brothers. Starring Robert Webb and David Mitchell

When a music track Jeremy and Super Hans wrote in the noughties becomes an unexpected hit in Germany, the pair fight over the rights to it. Although their friendship has broken down, it appears that Jez has unwittingly done something good, and he is left seeking revenge. Meanwhile, Mark has a play date with his son in a soft play centre, but things do not go to plan when his disastrous love life gets even more complicated and Ian gets lost in the giant 'kid farm'. Starring Robert Webb and David Mitchell